2013-10-08

Delayed aging is better investment than cancer, heart disease

Delayed aging is better investment than cancer, heart disease

With even modest gains in our scientific understanding of how to slow the aging process, an additional 5 percent of adults over the age of 65 would be healthy rather than disabled every year from 2030 to 2060, revealed the study in the October issue of Health Affairs.

Put another way, an investment in delayed aging would mean 11.7 million more healthy adults over the age of 65 in 2060. The analysis, from top scientists at USC, Harvard University, Columbia University, the University of Illinois at Chicago and other institutions, assumes research investment leading to a 1.25 percent reduction in the likelihood of age-related diseases. In contrast to treatments for fatal diseases, slowing aging would have no health returns initially, but would have significant benefits over the long term.

In the United States, the number of people aged 65 and over is expected to more than double in the next 50 years, from 43 million in 2010 to 106 million in 2060. About 28 percent of the current population over 65 is disabled.

"In the last half-century, major life expectancy gains were driven by finding ways to reduce mortality from fatal diseases," said lead author Dana Goldman, holder of the Leonard D. Schaeffer Director's Chair at the USC Schaeffer Center for Health Policy and Economics. "But now disabled life expectancy is rising faster than total life expectancy, leaving the number of years that one can expect to live in good health unchanged or diminished. If we can age more slowly, we can delay the onset and progression of many disabling diseases simultaneously."

The study showed significantly lower and declining returns for continuing the current research "disease model," which seeks to treat fatal diseases independently, rather than tackling the shared, underlying cause of frailty and disability: aging itself.

Lowering the incidence of cancer by 25 percent in the next few decades -- in line with the most favorable historical trends -- would barely improve population health over not doing anything at all, the analysis showed. The same is true of heart disease, the leading cause of death worldwide: About the same number of older adults would be alive but disabled in 2060 whether we do nothing or continue to combat cancer and heart disease individually. The findings are in line with earlier research showing that curing cancer completely would only increase life expectancy by about three years.

"Even a marginal success in slowing aging is going to have a huge impact on health and quality of life. This is a fundamentally new approach to public health that would attack the underlying risk factors for all fatal and disabling diseases," said corresponding author S. Jay Olshansky of the School of Public Health at the University of Illinois-Chicago. "We need to begin the research now. We don't know which mechanisms are going to work to actually delay aging, and there are probably a variety of ways this could be accomplished, but we need to decide now that this is worth pursuing."

Several lines of scientific inquiry have already shown how we might age more slowly, including studies of the genetics of "centenarians" and other long-lived people. Slowing the signs of biological aging has also been achieved in animal models, using pharmaceuticals or interventions such as caloric restriction.

But until now, no assessment has been made of the costs and health returns on developing therapies for delayed aging.

"We would be affecting every generation," Olshansky said. "This study is a benchmark in the world of public health."

The study showed that, with major advances in cancer treatment or heart disease, a 51-year-old can expect to live about one more year. A modest improvement in delaying aging would double this to two additional years -- and those years are much more likely to be spent in good health.

The increase in healthy years of life would have an economic benefit of approximately $7.1 trillion over the next five decades, the researchers find. Their analysis did not account for the potential cognitive benefits for older adults with research in delayed aging.

However, the results of the study also showed that improving the population of healthy, older adults will not lower overall health care spending. With research advances in delayed aging, more people would be alive past the age of 65, which means significantly higher outlays for Medicare and Medicaid despite less per-person spending on medical costs.

"Shifting the focus of medical investment to delayed aging instead of targeting diseases individually would lead to significant gains in physical health and social engagement," Goldman said. "We see extremely large population health benefits, and the benefits will extend to future generations. There are major fiscal challenges, but these are manageable with reasonable policy changes, and the economic value of such a shift is too large to ignore."

David Cutler of Harvard, John Rowe of the Mailman School of Public Health at Columbia, Pierre-Carl Michaud of the University of Quebec at Montreal, and Jeffrey Sullivan and Desi Peneva of Precision Health Economics were co-authors on the study.


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Making Martian clouds on Earth: Cloud-chamber experiments show that clouds on Mars form in much more humid conditions than clouds on Earth

Making Martian clouds on Earth: Cloud-chamber experiments show that clouds on Mars form in much more humid conditions than clouds on Earth

Oct. 7, 2013 — At first glance, Mars' clouds might easily be mistaken for those on Earth: Images of the Martian sky, taken by NASA's Opportunity rover, depict gauzy, high-altitude wisps, similar to our cirrus clouds. Given what scientists know about the Red Planet's atmosphere, these clouds likely consist of either carbon dioxide or water-based ice crystals. But it's difficult to know the precise conditions that give rise to such clouds without sampling directly from a Martian cloud.


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Researchers at MIT have now done the next-best thing: They've recreated Mars-like conditions within a three-story-tall cloud chamber in Germany, adjusting the chamber's temperature and relative humidity to match conditions on Mars -- essentially forming Martian clouds on Earth.

While the researchers were able to create clouds at the frigid temperatures typically found on Mars, they discovered that cloud formation in such conditions required adjusting the chamber's relative humidity to 190 percent -- far greater than cloud formation requires on Earth. The finding should help improve conventional models of the Martian atmosphere, many of which assume that Martian clouds require humidity levels similar to those found on Earth.

"A lot of atmospheric models for Mars are very simple," says Dan Cziczo, the Victor P. Starr Associate Professor of Atmospheric Chemistry at MIT. "They have to make gross assumptions about how clouds form: As soon as it hits 100 percent humidity, boom, you get a cloud to form. But we found you need more to kick-start the process."

Cziczo says the group's experimental results will help to improve Martian climate models, as well as scientists' understanding of how the planet transports water through the atmosphere. He and his colleagues have reported their findings in Journal of Geophysical Research: Planets.

Seeding Martian clouds

The team conducted most of the study's experiments during the summer of 2012 in Karlsruhe, Germany, at the Aerosol Interaction and Dynamics in the Atmosphere (AIDA) facility -- a former nuclear reactor that has since been converted into the world's largest cloud chamber.

The facility was originally designed to study atmospheric conditions on Earth. But Cziczo realized that with a little fine-tuning, the chamber could be adapted to simulate conditions on Mars. To do this, the team first pumped all the oxygen out of the chamber, and instead filled it with inert nitrogen or carbon dioxide -- the most common components of the Martian atmosphere. They then created a dust storm, pumping in fine particles similar in size and composition to the mineral dust found on Mars. Much like on Earth, these particles act as cloud seeds around which water vapor can adhere to form cloud particles.

After "seeding" the chamber, the researchers adjusted the temperature, first setting it to the coldest temperatures at which clouds form on Earth (around minus 81 degrees Fahrenheit). Throughout the experiment, they cranked the temperature progressively lower, eventually stopping at the chamber's lowest setting, around minus 120 Fahrenheit -- "a warm summer's day on Mars," Cziczo says.

By adjusting the chamber's relative humidity under each temperature condition, the researchers were able to create clouds under warmer, Earth-like temperatures, at expected relative humidities. These observations gave the researchers confidence in their experimental setup as they attempted to grow clouds at temperatures that approached Mars-like conditions.

Dialing the temperature down

Over a week, the group created 10 clouds, with each cloud taking about 15 minutes to form. The chamber is completed insulated, so the researchers used a system of lasers, which beam across the chamber, to detect cloud formation. Any clouds that form scatter laser light; this scattering is then detected and recorded by computers, which display the results -- the size, number, and composition of cloud particles -- for scientists outside the chamber.

By analyzing this data over the following six months, the researchers found that clouds that grew at the lowest temperatures required extremely high relative humidity in order for water vapor to form an ice crystal around a dust particle. Cziczo says it's unclear why Martian clouds need such humid conditions to take shape, but hopes to investigate the question further.

Toward that end, the group plans to return to Germany next fall, when the chamber will have undergone renovations, enabling it to perform cloud experiments at even lower temperatures -- conditions that may more closely mimic the icy atmosphere on Mars.

"If we want to understand where water goes and how it's transported through the atmosphere on Mars, we have to understand cloud formation for that planet," Cziczo says. "Hopefully this will move us toward the right direction."



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Business Good European sales in August

Business Good European sales in August

2013/10/07

TSMC fabEuropean chip sales were up 2% August on July and 5% up August 2013 on August 2012, says WSTS.

There was strong growth in discretes, microprocessors, sensors & actuators and total logic. Memory was up by 6.4%.

August European sales in were$ 2.9 billion.

YTD sales increased by 2.5% versus the same period in the year 2012.

Exchange rate effects continued to impact the data.

Measured in Euros, semiconductor sales were 2.204 billion Euros in August 2013, an increase of 1.2% versus the previous month and a decline of 1.1% versus the same month a year ago.

On a worldwide basis, semiconductor sales in August 2013 were US$ 25.873 billion, up 1.3% versus the previous month and up 6.4% versus the same month in 2012.



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Business IEF2013: Liars contest on nodes, says Mentor CEO.

Business IEF2013: Liars contest on nodes, says Mentor CEO.

2013/10/07

wallyWally Rhines, CEO of Mentor Graphics, agreed with Malcolm Penn, CEO of Future Horizons, that the measurements put on process nodes have become fictional.

Rhines told the IEF2013 meeting in Dublin that the progress of Moore’s Law, which Means transistor cost declined 30% every 18 months, and the dictates of the learning curve which meant that a doubling of the volume reduced the cost by 30%, meant thst process became all-important in the semiconductor business.

“Feature size became the metric of success, ” said Rhines, “then the hype started. There was the DRAM gate length, there was the actual gate length. The marketing departments came in and the claims got out of control on gate length.”

“Then they called in the referee in 1994 – the ITRS,” continued Rhines, “and they developed rules that volume is 10,000 units a year and minimum feature size – usually the poly gate – is the measurement.”

“Then the logic people asked for a separate rule and they took the first production shipment for logic.”

“The liars’ contest had to begin again,” said Rhines.

At 90nm Samsung actually had a 90nm gate length and at 70nm AMD erred on the side of conservatism by actually having a 35nm gate length, but then TI called a process 65nm where the the smallest gate was 130nm.

“At that point the ITRS said: ‘We give up’,and said it would make no more references go technology nodes,” said Rhines, “the ITRS told the industry: ‘You’re on your own’.”

“TSMC had a 20nm process on their technology roadmap. They asked themselves: ‘What to we call it?’ and called it a 16nm process,” said Rhines, “GlobalFoundries have a 20nm process.they asked: ‘What do we call it?’ and answered: ‘Ah Yes – 14nm’.”

The day before at IEF2013, Penn had said: “The current spin and hype is out of control, the industry needs to come out with a definition of what a process is.”



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Stroking could stress out your cat

Stroking could stress out your cat

Oct. 7, 2013 — A new study by an international team of animal behaviour specialists suggests that cats who reluctantly allow their owners to stroke them could be more stressed out than kitties who carefully avoid being petted.


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The surprise conclusion arose in a study conducted by researchers from the University of Lincoln, UK, University of Sao Paulo, Brazil, and University of Veterinary Medicine, Austria, which aimed to better understand how cats cope with living alongside humans and other felines in a single household.

Although many people consider cats to be solitary creatures, the collaborative research, published in the Journal Physiology and Behavior and presented to an international audience in Portugal in September 2013, revealed that cats can live happily together in groups, and that the number of cats is not necessarily a problem.

Sponsored by Ceva Animal Health, the scientists examined cats living alone, in pairs and in groups of three or four in the home, assessing levels of stress hormones on four occasions.

Although the number of cats in the home did not predict background stress levels, the researchers found that younger cats (less than two years old) living on their own were more stressed than younger ones living in the larger groups.

Evidence was also found to suggest that the owner's urge to pet their cat may be a stressful experience.

Professor Daniel Mills, Professor of Veterinary Behavioural Medicine at the University of Lincoln, said: "We chose stable households to look into this question and were quite surprised by the results. Despite typically living on their own in the wild, we have known for some time that cats come together when resources like food are concentrated in a single area, for example when people feed strays. However, it might be that they do this out of need and it is still stressful for them, because they are not a naturally social species.

"Many people keep groups of cats in their home and although they might seem happy together, some people have argued that because this is an unnatural set up, it is not good for their welfare. Our research shows this is not necessarily the case. It seems even if they are not best friends, cats may be able to organise themselves to avoid each other without getting stressed. Also, and I think very intriguingly, our data suggests that cats who tolerate, rather than enjoy or dislike being petted, seem to be the most stressed."

Professor Mills explains that those cats that dislike being petted, can probably avoid this interaction if they live with another cat which enjoys or tolerates it, and so do not get stressed.

He added: "It seems that those cats on whom the owner imposes him or herself are the ones we need to be most concerned about. The results also reinforce the importance of ensuring that you give all individuals control over their environment, so if you have several cats you should give them the choice of sharing or having their own special areas to eat, drink and go to the toilet."



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UltraHaptics: It's magic in the air

UltraHaptics: It's magic in the air

Multi-touch surfaces offer easy interaction in public spaces, with people being able to walk-up and use them. However, people cannot feel what they have touched. A team from the University of Bristol's Interaction and Graphics (BIG) research group have developed a solution that not only allows people to feel what is on the screen, but also receive invisible information before they touch it.

The research paper, to be presented at the ACM Symposium on User Interface Software and Technology (UIST) 2013 by Tom Carter from the Department of Computer Science, will unveil UltraHaptics, a system designed to provide multipoint, mid-air haptic feedback above a touch surface.

UltraHaptics uses the principle of acoustic radiation force where a phased array of ultrasonic transducers is used to exert forces on a target in mid-air. Haptic sensations are projected through a screen and directly onto the user's hands.

The use of ultrasonic vibrations is a new technique for delivering tactile sensations to the user. A series of ultrasonic transducers emit very high frequency sound waves. When all of the sound waves meet at the same location at the same time, they create sensations on a human's skin.

By carrying out technical evaluations, the team have shown that the system is capable of creating individual points of feedback that are far beyond the perception threshold of the human hand. The researchers have also established the necessary properties of a display surface that is transparent to 40kHz ultrasound.

The results from two user studies have demonstrated that feedback points with different tactile properties can be distinguished at smaller separations. The researchers also found that users are able to identify different tactile properties with training.

Finally, the research team explored three new areas of interaction possibilities that UltraHaptics can provide: mid-air gestures, tactile information layers and visually restricted displays, and created an application for each.

Tom Carter, PhD student in the Department of Computer Science's BIG research group, said: "Current systems with integrated interactive surfaces allow users to walk-up and use them with bare hands. Our goal was to integrate haptic feedback into these systems without sacrificing their simplicity and accessibility.

"To achieve this, we have designed a system with an ultrasound transducer array positioned beneath an acoustically transparent display. This arrangement allows the projection of focused ultrasound through the interactive surface and directly onto the users' bare hands. By creating multiple simultaneous feedback points, and giving them individual tactile properties, users can receive localised feedback associated to their actions."

A video demonstrating UltraHaptics is available on YouTube.


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SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

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Materials RD EU graphene researchers meet in Sweden

Materials RD EU graphene researchers meet in Sweden

2013/10/07

p-022585-00-06hGraphene researchers from all over Europe meet this week in Gothenburg, Sweden.

Graphene research is very active in Europe and the EU-funded Graphene Flagship conference will host 74 research partners from 17 European countries.

Researchers, which includes teams at Manchester and Cambridge in the UK, are working to  take graphene and related ultra-thin layered materials from academic laboratories to commercial products.

The researchers believe the new semiconductor material technology can potentially “revolutionise multiple industries and create economic growth and new jobs in Europe”.

The event takes place at Chalmers University of Technology in Gothenburg, Sweden on October 10-11.

Graphene Flagship is an FET Flagship initiative by the European Commission.



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Bile salts: Sea lampreys' newest scent of seduction

Bile salts: Sea lampreys' newest scent of seduction

New research at Michigan State University shows that bile salts, secreted from the liver and traditionally associated with digestive functions, are being used as pheromones by sea lampreys. The interesting twist, though, is that this scent has evolved as the invasive species' cologne of choice.

The evolution of bile salts from digestive aid to pheromone, featured in the current issue of the Proceedings of the Royal Society B, mirrors humans' adaptation of perfume.

"It's similar to how perfume has evolved in our society," said Tyler Buchinger, one of the lead authors and MSU doctoral student. "Perfume was first used to mask body odor due to a societal stigma against daily bathing. Today, in many cases, it exemplifies romance and is used to attract mates."

Bile salts, like perfumes and colognes, were not first used as sex signals. Their primary use is to process fats. Over many hundreds of years, though, they have evolved to become beacons of sexuality in addition to their digestive duties. The evolution of males emitting this pheromone appears to be a result of female lampreys' receiver bias, or their desire to mate sparked by the fragrance.

Since time travel is out of the question, Buchinger and Weiming Li, one of the lead authors and MSU professor of fisheries and wildlife, tested the evolution theory on silver lampreys, a species native to Michigan and recognized as a more-ancient species than sea lampreys.

The researchers demonstrated that sea lampreys and silver lampreys smell bile salts and acknowledge them as attractants. The difference, however, is sea lampreys become sexually active while silver lampreys do not.

In the field, sea lampreys and silver lampreys were drawn upstream by the smell of bile salts. Only the sea lampreys, though, swam in looking for love and ready to spawn.

Silver lampreys are one of four native lamprey species in Michigan; the others are the chestnut, American brook and northern brook. Knowing that a distinct scent affects an invasive species differently from the native fauna they are displacing is a research angle worth pursuing, Li said.

"This mating call is quite effective, and it has helped sea lampreys thrive," he said. "Knowing that bile salts cause sea lampreys to react differently than our native species, which have long been part of our ecosystem, could eventually lead to better ways to control sea lampreys."

Nick Johnson of the USGS Great Lakes Science Center also contributed to this research.

Li's work is funded in part by the Great Lakes Fishery Commission, National Science Foundation and MSU AgBioResearch.


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Extrusive volcanism formed the Hawaiian Islands

Extrusive volcanism formed the Hawaiian Islands

Oct. 7, 2013 — A recent study by researchers at the University of Hawaii -- Manoa (UHM) School of Ocean and Earth Science and Technology (SOEST) and the University of Rhode Island (URI) changes the understanding of how the Hawaiian Islands formed. Scientists have determined that it is the eruptions of lava on the surface, extrusion, which grow Hawaiian volcanoes, rather than internal emplacement of magma, as was previously thought.


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Before this work, most scientists thought that Hawaiian volcanoes grew primarily internally -- by magma intruding into rock and solidifying before it reaches the surface. While this type of growth does occur, along Kilauea's East Rift Zone (ERZ), for example, it does not appear to be representative of the overall history of how the Hawaiian Islands formed. Previous estimates of the internal-to-extrusive ratios (internally emplaced magma versus extrusive lava flow) were based on observations over a very short time frame, in the geologic sense.

Ashton Flinders (M.S. from UHM), lead author and graduate student at URI, and colleagues compiled historical land-based gravity surveys with more recent surveys on the Big Island of Hawaii (in partnership with Jim Kauahikaua of the U.S. Geological Survey -- Hawaii Volcano Observatory) and Kauai, along with marine surveys from the National Geophysical Data Center and from the UH R/V Kilo Moana. These types of data sets allow scientists to infer processes that have taken place over longer time periods.

"The discrepancy we see between our estimate and these past estimates emphasizes that the short term processes we currently see in Hawaii (which tend to be more intrusive) do not represent the predominant character of their volcanic activity," said Flinders.

"This could imply that over the long-term, Kilauea's ERZ will see less seismic activity and more eruptive activity that previously thought. The 3-decade-old eruption along Kilauea's ERZ could last for many, many more decades to come," said Dr. Garrett Ito, Professor of Geology and Geophysics at UHM and co-author.

"I think one of the more interesting possible implications is how the intrusive-to-extrusive ratio impacts the stability of the volcano's flank. Collapses occur over a range of scales from as large as the whole flank of a volcano, to bench collapses on the south coast of Big Island, to small rock falls. " said Flinders. Intrusive magma is more dense and structurally stronger than lava flows. "If the bulk of the islands are made from these weak extrusive flows then this would account for some of the collapses that have been documented, but this is mainly just speculation as of now."

The authors hope this new density model can be used as a starting point for further crustal studies in the Hawaiian Islands.



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2013-10-07

RF, Microwave Optoelectronics All-in-one wireless power chip from Linear

RF, Microwave Optoelectronics All-in-one wireless power chip from Linear

2013/10/07

UntitledLinear Technology has for the first time combined a wireless power receiver with a constant-current/constant-voltage battery charger, to operate as a complete wireless power transfer system comprised of transmit circuitry, transmit coil, receive coil and receive circuitry.

The LTC4120  has been designed to work with the supplier’s discrete resonant transmitter reference design or to work with off-the-shelf transmitters from PowerbyProxi, a New Zealand-based wireless power firm.

PowerbyProxi transmitters support simultaneous charging of multiple receivers with a single transmitter and foreign object detection to prevent excessive heating during transmit faults.

The LTC4120 accepts a rectified 4.2V to 40V input from the receive coil to power a full-featured constant-current/constant-voltage 400mA battery charger that includes programmable charge current, a programmable 3.5V to 11V battery float voltage with ±1% accuracy, battery preconditioning with half-hour timeout, bad battery fault detection, NTC thermal protection, charge status and a 2-hour safety termination timer.

A technique known as dynamic harmonization control (DHC) is designed to optimise wireless power transfer across a variety of conditions while providing thermal management and overvoltage protection.

“This technique modulates the resonant frequency of the receiver tank to provide lossless adjustment of the power received as well as the power transmitted to enable an efficient and robust solution for wirelessly charging battery-powered devices,” said Linear.

“The LTC4120 is the first result of an ongoing partnership between Linear Technology and PowerbyProxi, a technology company focused on providing real world wireless power solutions to the market,” said Don Paulus, general manager of Linear Technology’s power products group.

The LTC4120 is available in a low profile (0.75mm) 16-pin 3mm x 3mm QFN package with backside metal pad for excellent thermal performance.



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What evolved first, a dexterous hand or an agile foot?

What evolved first, a dexterous hand or an agile foot?

Combining monkey and human behavior, brain imaging, and fossil evidence, a research team led by neurobiologist Dr. Atsushi Iriki and including Dr. Gen Suwa, an anthropologist from the University of Tokyo Museum, have overturned the common assumption that manual dexterity evolved after the development of bipedal locomotion freed hominid hands to use fingers for tool manipulation.

In a study published today in Philosophical Transactions of the Royal Society, the researchers employed functional magnetic resonance imaging in humans and electrical recording from monkeys to locate the brain areas responsible for touch awareness in individual fingers and toes, called somatotopic maps. With these maps, the researchers confirmed previous studies showing that single digits in the hand and foot have discrete neural locations in both humans and monkeys.

However, the researchers found new evidence that monkey toes are combined into a single map, while human toes are also fused into a single map, but with the prominent exception of the big toe, which has its own map not seen in monkeys. These findings suggest that early hominids evolved dexterous fingers when they were still quadrupeds. Manual dexterity was not further expanded in monkeys, but humans gained fine finger control and a big toe to aid bipedal locomotion.

"In early quadruped hominids, finger control and tool use were feasible, while an independent adaptation involving the use of the big toe for functions like balance and walking occurred with bipedality," the authors explained.

The brain study was supported by analysis of the well-preserved hand and feet bones of a 4.4 million year-old skeleton of the quadruped hominid Ardipithecus ramidus, a species with hand dexterity that preceded the human-monkey lineage split.

The findings suggest that the parallel evolution of two-legged locomotion and manual dexterity in hands and fingers in the human lineage were a consequence of adaptive pressures on ancestral quadrupeds for balance control by foot digits while retaining the critical capability for fine finger specialization.

"Evolution is not usually thought of as being accessible to study in the laboratory," stated Dr. Iriki, "but our new method of using comparative brain physiology to decipher ancestral traces of adaptation may allow us to re-examine Darwin's theories."


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